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Lehman College

Department of Biology

Moira Publication



  • Zhong X, Persaud L, Muharam H, Francis A, Das D, Aktas BH, Sauane M. Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation. Cancers, 2018 May 22;10(5).
  • O'Connor, N.A..  EinbondRedenti, S., Sauane, M., Jitianu, A. Self-degradable curcumin polymer with anti-cancer activity.  Applied Polymer Science. 2018 August 27, 135, 46867. 
  • Kasteri J, Das D, Zhong X, Persaud L, Francis A, Muharam H, Sauane M. Translation Control by p53. Cancers. 2018 May 5;10(5). 
  • Persaud L, Zhong X, Alvarado G, Do W, Dejoie J, Zybtseva A, Aktas BH, Sauane M. eIF2α Phosphorylation Mediates IL24-Induced Apoptosis through Inhibition of Translation. Mol Cancer Res. 2017 Aug;15(8):1117-1124.
  • Persaud L, De Jesus D, Brannigan O, Richiez-Paredes M, Huaman J, Alvarado G, Riker L, Mendez G, Dejoie J, Sauane M. Mechanism of Action and Applications of Interleukin 24 in Immunotherapy. Int J Mol Sci. 2016 Jun 2;17(6).
  • Unachukwu UJ, Warren A, Li Z, Mishra S, Zhou J, Sauane M, Lim H, Vazquez M, Redenti S. Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina. Sci Rep. 2016 Mar 3;6:22392.
  • Das D, Persaud L, Dejoie J, Happy M, Brannigan O, De Jesus D, Sauane M. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates caspases in human prostate cancer cells through sigma 1 receptor. Biochem Biophys Res Commun. 2016 Feb 5;470(2):319-323.
  • Cruz, A., Nguyen, B., Sauane M, Lopez, G.E. Structural and functional characterization of IL-24 based on atomistic molecular modeling. Chemistry Letters. 2016 Dec 22;45(3):327-329.
  • Happy M, Dejoie J, Zajac CK, Cortez B, Chakraborty K, Aderemi J, Sauane M. Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation. Biochem Biophys Res Commun. 2015 Jan 9;456(2):683-8.
  • Unachukwu UJ, Sauane M, Vazquez M, Redenti S. Microfluidic generated EGF-gradients induce chemokinesis of transplantable retinal progenitor cells via the JAK/STAT and PI3kinase signaling pathways. PLoS One. 2013 Dec 23;8(12):e83906.
  • Do W, Herrera C, Mighty J, Shumskaya M, Redenti SM, Sauane M. Sigma 1 Receptor plays a prominent role in IL-24-induced cancer-specific apoptosis. Biochem Biophys Res Commun. 2013 Sep 20;439(2):215-20.
  • Sauane, M., Su, Z.Z., Dash, R., Liu, X., Norris, J.A., Sarkar, D, Allegood, J.C., Dent, P., Sarah Spiegel, S., and Fisher, P.B. "Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis".  J. Cell Physiol. 222(3): 546-55 (2010).
  • Sauane, M., Su, Z.Z., Gupta, P., Lebedeva, I.V., Dent, P., Sarkar, D., and Fisher, P.B “Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis”. Proceedings of the National Academy of Sciences of the United States of America. 105(28):9763-8 (2008).
  • Sarkar, D., Lebedeva, I.V., Gupta, P., Emdad, L., Sauane, M., Dent, P., Curiel, D.T., Fisher, P.B.. “Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?”. Expert Opin Biol Ther. 7(5):577-86(2007).
  • Turner, D.P., Moussa, O., Sauane, M., Fisher, P.B., Watson, D.K.. “Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer”.  Cancer Res. 15;67(4):1618-25 (2007).
  • Sauane, M., Gupta, P., Lebedeva, I.V., Su, Z.Z., Sarkar, D., Randolph, A., Valerie, K., Gopalkrishnan, R.V., and Fisher, P.B.. “N-Glycosylation of MDA-7/IL-24 Is Dispensable for Tumor Cell– Specific Apoptosis and Bystander Antitumor Activity”. Cancer Res. 66: 11869- 11877 (2006).
  • Gupta, P., Su, Z., Lebedeva, I.V.,  Sarkar, D., Sauane, M., Emdad, L., Bachelor, M.A., Grant, S., Curiel, D.T., Dent, P., Fisher, P.B.. “mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine”.  Pharmacology & Therapeutics 111: 596 – 628 (2006).
  • Dekanty, A., Sauane, M., Cadenas, B., Coluccio, F., Barrio, M., Casala, J., Paciencia, M., Rogers, F., Coso, O. A., Piwien-Pilipuk, G., Rudland, P. S., and de Asua, L.J.. “Leukemia inhibitory factor induces DNA synthesis in Swiss mouse 3T3 cells independently of cyclin D1 expression through a mechanism involving MEK/ERK1/2 activation”. J Biol. Chem. 281:6136-6143 (2006).
  • Su, Z.Z., Emdad, L., Sauane, M., Lebedeva, I.V.*, Sarkar, D., Gupta, P., James, C.D., Randolph, A., Valerie, K., Walter, M.R., Dent, P., and Fisher, P.B. “Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells”. Oncogene 24, 7552-7566 (2005).
  • Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Gupta, P., Nemunaitis, J., Cunningham, C., Yacoub, A., Dent, P., and Fisher, P.B. “mda-7/IL-24: exploiting cancer's Achilles' heel”. Mol Ther 11, 4-18 (2005).
  • Sauane, M., Gopalkrishnan, R.V., Choo, H.T., Gupta, P., Lebedeva, I.V., Yacoub, A., Dent, P., and Fisher, P.B. “Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein”. Oncogene 23, 7679-7690 (2004).
  • Sauane, M., Lebedeva, I.V., Su, Z.Z., Choo, H.T., Randolph, A., Valerie, K., Dent, P., Gopalkrishnan, R.V., and Fisher, P.B. “Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways. Cancer Res. 64:2988-93 (2004)
  • Sauane, M., Coso, O.A., Giulianelli, S., Giraldes, A.N., Rudland, P.S., and Jimenez de Asua, L. “Leukaemia Inhibitory Factor or Oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication”. Biochem. Biophys. Res. Commun. 313: 926-930. (2004).
  • Gopalkrishnan, R.V., Sauane, M and Fisher, P.B. “Cytokine and Tumor Cell Apoptosis inducing activity of mda-7/IL-24”. Int Immunopharmacol. 4:635-647 (2004).
  • Sauane, M., Gopalkrishnan, R.V., Lebedeva, I.V., Mei, M.X., Sarkar, D., Su, Z.Z. Kang, D.-c. Dent, P. Pestka, S., and Fisher, P. B. "Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways." J Cellular Physiol. 196: 334-345. (2003).
  • Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Lebedeva, I.V., Dent, P., Pestka, S., and Fisher, P.B. “Mda-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine”. Cytokine and Growth Factor Reviews 14: 35-51. (2003).
  • Su, Z.Z., Lebedeva, I.V., Sarkar, D., Gopalkrishnan, R.V., Sauane, M., Sigmon, C., Yacoub, A., Valerie, K., Dent, P., and Fisher, P.B. “Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner”. Oncogene. 22,1164-1180. (2003).
  • Sarkar, D., Su, Z.Z., Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Valerie, K., Dent, P., and Fisher, P.B. “mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK”. Proceedings of the National Academy of Sciences of the United States of America 99: 10054-10059. (2002).
  • Sauane, M., Correa, L., Rogers, F., Krasnapolski, M., Barraclough, R., Rudland, Ph.S. and Jimenez de Asua, L. “Prostaglandin F2a induces cyclin D1 expression and DNA synthesis via early signaling mechanisms in Swiss 3T3 Cells” Biochem. Biophy. Res. Comm 270, 11-16 (2000).
  • Schere Levy, C., Sauane, M., Rudland, Ph.S. and Jimenez de Asua, L. “Leukaemia inhibitory factor induces mitogenesis in Swiss 3T3 cells and selective enhancement via a variety of signalling events” Biochem. Biophy. Res. Comm  236, 814-818 (1997).